DR3 (TNFRSF25) (1-210) Rabbit Polyclonal Antibody

CAT#: AP23609PU-N

DR3 (TNFRSF25) (1-210) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug whole cell lysate). A:Hep G2. 7.5% SDS PAGE. TNFRSF25 antibody diluted at 1/1000

• 

  Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 210 of Human DR3
• Specificity: This antibody reacts to Tnf Receptor Superfamily, Member 12 (TNFRSF12) (TNFRSF25) at aa 1-210.
• Formulation: 0.1 M Tris-glycine, pH 7.0 containing 10% Glycerol and 0.01% Thimerosal
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody (in aliqouts) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: tumor necrosis factor receptor superfamily member 25
• Database Link:
  Entrez Gene 8718 Human
  UniProt ID Q93038
• Background: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation.
• Synonyms: APO3, DDR3, TNFRSF12, WSL, WSL1, Apo-3, AIR, Death receptor 3, LARD, Protein WSL, Protein WSL-1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction