KMT5A (Center) Rabbit Polyclonal Antibody

CAT#: AP17740PU-N

KMT5A (Center) rabbit polyclonal antibody

Product Images

Western blot analysis of SETD8 antibody (Center) in 293 cell line lysates (35ug/lane). SETD8 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human SETD8
• Specificity: This antibody reacts to SETD8.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: lysine methyltransferase 5A
• Database Link:
  Entrez Gene 387893 Human
  UniProt ID Q9NQR1
• Background: SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
• Synonyms: SET8, PRSET7, PR-Set7, KMT5A

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation