Estrogen Receptor 1 (ESR1) Rabbit Polyclonal Antibody
Other products for "ESR1"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | Western Blot: 1/500 - 1/1000. Immunohistochemistry on paraffin sections: 1/50 - 1/100. Immunofluorescence: 1/100 - 1/200. |
Reactivities | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic non-phosphopeptide derived from human Estrogen Receptor-alpha around the phosphorylation site of serine118 (Q-L-SP-P-F). |
Specificity | Estrogen Receptor-alpha antibody detects endogenous levels of total Estrogen Receptor-alpha protein. |
Formulation | PBS(without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid purified IgG fraction |
Concentration | lot specific |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | estrogen receptor 1 |
Database Link | |
Background | Estrogen Receptor alpha is a 65 kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies. |
Synonyms | ER alpha, Estradiol receptor, ESR1, ESR, NR3A1 |
Reference Data |
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