BCR pTyr177 Rabbit Polyclonal Antibody
Other products for "BCR"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Suitable for use in Western blot (1/500-1/1000) and Immunohistochemistry on Paraffin-Embedded Sections (1/50-1/100). |
Reactivities | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | The antiserum was produced against synthesized phosphopeptide derived from Human Bcr around the phosphorylation site of Tyrosine 177 (P-F-Yp-V-N). |
Specificity | This antibody detects endogenous levels of Bcr only when phosphorylated at Tyrosine 177. |
Formulation | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol State: Aff - Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Purification | Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site. |
Conjugation | Unconjugated |
Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Gene Name | BCR, RhoGEF and GTPase activating protein |
Database Link | |
Background | The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling. |
Synonyms | Breakpoint cluster region protein, BCR1, D22S11, NY-REN-26 |
Note | Molecular Weight: 210 kDa |
Reference Data |
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