Her2 (ERBB2) pTyr1221/1222 Rabbit Polyclonal Antibody

CAT#: AP01600PU-N

Her2 (ERBB2) pTyr1221/1222 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of p-HER2 (Y1221 +Y1222) antibody (Cat.-No.: AP01600PU-N) in extracts from SK-OV3 cells treated with EGF.

• 

  Immunohistochemistry (IHC) analysis of HER2 pTyr1221+pTyr1222 antibody (Cat.-No.: AP01600PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
  Immunoprecipitation: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of HER2 pTyr1221/1222 protein.
• Formulation: Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Predicted Protein Size: ~ 150-170 kDa
• Gene Name: erb-b2 receptor tyrosine kinase 2
• Database Link:
  Entrez Gene 2064 Human
  UniProt ID P04626
• Background: ErbB 2 is a receptor tyrosine kinase of the ErbB 2 family. It is closely related instructure to the epidermal growth factor receptor. ErbB 2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.
• Synonyms: HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19