PARK7 Rabbit Polyclonal Antibody
Other products for "PARK7"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Western Blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 50-97 of Human PARK7 / DJ-1. |
Specificity | This antibody detects endogenous levels of DJ-1 protein. (region surrounding Ala87) |
Formulation | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Predicted Protein Size | ~20 kDa |
Gene Name | Parkinsonism associated deglycase |
Database Link | |
Background | The DJ-1 gene encodes a highly-conserved protein which is implicated in a number of cell processes. DJ-1 was first identified as a novel oncogene that transformed mouse NIH/3T3 cells in cooperation with activated Ras. Additionally, DJ-1 was cloned in rat as SP22 or CAP-1, and found to be an infertilityrelated sperm protein whose expression is reduced in sperm treated with toxicants. DJ-1 also positively regulates the androgen receptor (AR) by forming a complex with PIASxalpha, a negative regulator of AR. The gene encoding human DJ-1 maps to chromosome 1p36.33-p36.12, a region identified as a hot spot of chromosome abnormalities in several tumor cells. Subsequently, mutations in the DJ-1 gene have been implicated in Parkinsons disease, and loss of DJ-1 function leads to neurodegeneration. DJ-1 is a ubiquitously expressed protein that is induced in response to growth stimuli and translocates from the cytoplasm to the nucleus during the S phase of the cell cycle. |
Synonyms | Oncogene DJ1, Parkinson disease protein 7 |
Reference Data |
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