CD160 Mouse Monoclonal Antibody [Clone ID: BY55]
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Specifications
Product Data | |
Clone Name | BY55 |
Applications | FC, IP |
Recommended Dilution | Flow cytometry. Immunoprecipitation. |
Reactivities | Human |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | Human NK cell line YT2C2 |
Specificity | This antibody recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160. |
Formulation | Tris buffered saline (TBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 8.0 |
Concentration | lot specific |
Purification | Ion exchange chromatography (> 95% pure by SDS-PAGE) |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | CD160 molecule |
Database Link | |
Background | CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent. |
Synonyms | BY55 |
Reference Data |
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