CD160 Mouse Monoclonal Antibody [Clone ID: BY55]

CAT#: AM26770PU-N

CD160 mouse monoclonal antibody, clone BY55, Purified

Specifications

Product Data

• Clone Name: BY55
• Applications: FC, IP
• Recommended Dilution: Flow cytometry.
  Immunoprecipitation.
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: Human NK cell line YT2C2
• Specificity: This antibody recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160.
• Formulation: Tris buffered saline (TBS)
  State: Purified
  State: Liquid Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 8.0
• Concentration: lot specific
• Purification: Ion exchange chromatography (> 95% pure by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: CD160 molecule
• Database Link:
  Entrez Gene 11126 Human
  UniProt ID O95971
• Background: CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
• Synonyms: BY55