CBX3 Mouse Monoclonal Antibody [Clone ID: 2MOD-1G6]

CAT#: AM26741PU-N

CBX3 mouse monoclonal antibody, clone 2MOD-1G6, Purified

Product Images

Immunohistochemistry on paraffin sections: Human brain cortex, stained withAM26741PU-N.

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  Immunohistochemistry on paraffin sections: Swine brain cortex, stained withAM26741PU-N.

Specifications

Product Data

• Clone Name: 2MOD-1G6
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 0.4 µg/ml (1/500).
  Suggested positive control: Human / Porcine brain cortex.
• Reactivities: Human, Mouse, Porcine
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant mouse HP1γ
• Specificity: This antibody detects HP1γ.
• Formulation: Phosphate buffered saline pH 7.2 (PBS)
  State: Purified
  State: Lyophilized purified Ig fraction
  Stabilizer: 5 mg/ml bovine serum albumin (BSA)
  Preservative: 0.01 % Kathon
• Reconstitution Method: Reconstitute by adding 0.5 ml distilled water. This stock solution contains 0.2 mg/ml IgG.
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 month or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  UniProt ID P23198
• Background: Heterochromatin Protein 1 (HP1) ("Chromobox Homolog", CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functi ons in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C-terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post-translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.
• Synonyms: Chromobox protein homolog 3, HECH, HP1 gamma, HP1-gamma, HP1Hs-gamma