ARHGEF4 (143-271) Mouse Monoclonal Antibody [Clone ID: ARHGEF-08]
CAT#: AM26710PU-N
ARHGEF4 (143-271) mouse monoclonal antibody, clone ARHGEF-08, Aff - Purified
Conjugation: PE
Other products for "ARHGEF4"
Specifications
Product Data | |
Clone Name | ARHGEF-08 |
Applications | FC, WB |
Recommended Dilution | Flow Cytometry: Intracellular staining.
Western blot. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant fragment of human ARHGEF4 (amino acids 143-271) |
Specificity | The mouse monoclonal antibody ARHGEF-08 recognizes Human intracellular protein ARHGEF4 / ASEF1, approx. 80 kDa guanine nucleotide exchange factor specific for Rac1 and Cdc42. |
Formulation | PBS, pH~7.4 State: Aff - Purified State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein-A |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | Rho guanine nucleotide exchange factor 4 |
Database Link | |
Background | ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF 1 (adenomatous polyposis coli – stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), Pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration. |
Synonyms | KIAA1112, ASEF |
Reference Data |
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