RTN3 Mouse Monoclonal Antibody [Clone ID: 1E11]

CAT#: AM06407SU-N

RTN3 mouse monoclonal antibody, clone 1E11, Ascites

Product Images

Confocal immunofluorescence analysis of Hela (A), A431 (B) and THP-1 (C) cells using RTN3 antibody Cat.-No AM06407SU-N (green). Blue: DRAQ5 fluorescent DNA dye.

Specifications

Product Data

• Clone Name: 1E11
• Applications: IF
• Recommended Dilution: ELISA: 1/10000.
  Immunofluorescence: 1/200 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of RTN3 expressed in E. Coli.
• Specificity: Recognizes Reticulon 3 (RTN3).
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 113 kDa
• Gene Name: reticulon 3
• Database Link:
  Entrez Gene 10313 Human
  UniProt ID O95197
• Background: The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.
• Synonyms: ASYIP, NSPL2, NSPLII, NSP-like protein 2