TIMP1 Mouse Monoclonal Antibody [Clone ID: 2A5]

CAT#: AM05381PU-N

TIMP1 mouse monoclonal antibody, clone 2A5, Purified

Product Images

Left: Immunohistochemical staining of human colon carcinoma tissue using TIMP-1 antibody. Right: Western blot using TIMP-1 antibody against recombinant human TIMP-1 proenzyme (400 ng/lane).

Specifications

Product Data

• Clone Name: 2A5
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on paraffin sections: 1 - 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice
• Specificity: This antibody reacts to Tissue Inhibitor of Matrix Metalloproteinase 1.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: TIMP metallopeptidase inhibitor 1
• Database Link:
  Entrez Gene 7076 Human
  UniProt ID P01033
• Background: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.
• Synonyms: TIMP-1, TIMP, Tissue inhibitor of metalloproteinases, Metalloproteinase inhibitor 1, EPA, CLGI