LEF1 (all isoforms) Mouse Monoclonal Antibody [Clone ID: 1C3.1D10]
CAT#: AM05276PU-N
LEF1 (all isoforms) mouse monoclonal antibody, clone 1C3.1D10, Purified
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Specifications
Product Data | |
Clone Name | 1C3.1D10 |
Applications | WB |
Recommended Dilution | Western Blot. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant full length LEF-1 protein. |
Specificity | This antibody detects all LEF-1 isoforms by Western blot and does not cross-react with TCF-1 or TCF-4. Recognizes an epitope in amino acids 256-308 of LEF-1. This region is between the transactivation domain and the HMG binding domain of LEF-1 and is conserved in all LEF-1 isoforms. |
Formulation | PBS containing 0.08% Sodium Azide as preservative State: Purified State: Liquid (sterile filtered) purified IgG fraction. |
Concentration | lot specific |
Purification | Protein A/G Chromatography |
Conjugation | Unconjugated |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | lymphoid enhancer binding factor 1 |
Database Link | |
Background | Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. |
Synonyms | Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha |
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