Rb (RB1) Mouse Monoclonal Antibody [Clone ID: XZ104]

CAT#: AM05254PU-N

Rb (RB1) mouse monoclonal antibody, clone XZ104, Purified

Specifications

Product Data

• Clone Name: XZ104
• Applications: IP
• Recommended Dilution: Immunoprecipitation.
  This antibody is not recommended for Western blotting or Immunohistochemistry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence.
• Formulation: PBS containing 0.08% Sodium Azide as preservative.
  State: Purified
  State: Liquid (sterile filtered) purified IgG fraction.
• Concentration: lot specific
• Purification: From ascites.
• Conjugation: Unconjugated
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: RB transcriptional corepressor 1
• Database Link:
  Entrez Gene 5925 Human
  UniProt ID P06400
• Background: Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.
• Synonyms: Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC