DcR2 (TNFRSF10D) Mouse Monoclonal Antibody [Clone ID: TRAIL-R4-01]
CAT#: AM03039RP-N
DcR2 (TNFRSF10D) mouse monoclonal antibody, clone TRAIL-R4-01, PE
Conjugation: FITC
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Specifications
Product Data | |
Clone Name | TRAIL-R4-01 |
Applications | FC |
Recommended Dilution | Flow Cytometry: 3 µg/ml. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | TRAIL-R4 (aa 1-210) - hIgGhc fusion protein |
Specificity | The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells. |
Formulation | PBS containing 15 mM Sdium Azide as preservative and 0.2% (w/v) high-grade (Protease free) BSA as a stabilizing agent. Label: PE State: Liquid purified IgG fraction. Label: R-Phycoerythrin under optimum conditions |
Concentration | lot specific |
Purification | Size-Exclusion Chromatography. |
Conjugation | PE |
Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid prolonged exposure to light. |
Stability | Shelf life: one year from despatch. |
Gene Name | tumor necrosis factor receptor superfamily member 10d |
Database Link | |
Background | TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4). |
Synonyms | TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity |
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