Il17a Rat Monoclonal Antibody [Clone ID: TC11-8H4]

CAT#: AM01281PU-N

Il17a rat monoclonal antibody, clone TC11-8H4, Purified

Specifications

Product Data

• Clone Name: TC11-8H4
• Applications: ELISA
• Recommended Dilution: ELISA.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant mouse IL-17 expressed in E. coli
• Specificity: This antibody recognises mouse Interleukin 17.
• Formulation: Borate buffered saline, pH8.2
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store the antibody in aliquots at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 17A
• Database Link:
  Entrez Gene 16171 Mouse
  UniProt ID Q62386
• Background: Interleukin 17 is a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217).
  IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.
• Synonyms: IL-17A, IL17, IL-17, CTLA8, CTLA-8