CD13 (ANPEP) Mouse Monoclonal Antibody [Clone ID: 22A5]

CAT#: AM00642BT-N

CD13 (ANPEP) mouse monoclonal antibody, clone 22A5, Biotin

Specifications

Product Data

• Clone Name: 22A5
• Applications: FC, IHC
• Recommended Dilution: Suitable for use in Flow Cytometry and Immunohistochemistry (acetone-fixed frozen sections).
  We recommend using 1 µg to stain 1.0 x 10e6 cells in Flow Cytometric applications.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A cell suspension containing osteoclasts from osteoclastomas
• Specificity: This antibody recognizes the (Mr 150-170kDa) cell surface glycoprotein expressed in a pan-myeloid fashion. This antibody also reacts with osteoclasts in giant cell tumors of bone (osteoclastoma), clear cell chondrosarcoma and aneurysmal bone cysts.
• Formulation: 0.01M PBS, pH 7.2 containing 2mM EDTA, 1% BSA as stabilizer and 0.09% Sodium Azide as preservative.
  Label: Biotin
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Protein G Chromatography.
• Conjugation: Biotin
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: alanyl aminopeptidase, membrane
• Database Link:
  Entrez Gene 290 Human
  UniProt ID P15144
• Background: CD13 also known as Aminopeptidase N is a zinc dependent exopeptidase which cleaves amino acids from the N-termini of target proteins including neuropeptides and cytokines. CD13 is expressed on all cells of the myeloid lineage as well as epithelial cells of the intestine, placenta, liver and kidney. CD13 is upregulated in a number of tumour types including lung, melanoma, thyroid and hepatocarcinoma and has been shown to correlate with poor prognosis. CD13 is a crucial molecule in tumour angiogenesis. CD13 is also the receptor for viruses from the coronavirus family.
• Synonyms: Aminopeptidase N, ANPEP, APN, PEPN