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HomeAll Cancer Mutant ClonesNRAS Mutants

Description of the mutations of NRAS (NM_002524) Mutants


Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
Proc. Natl. Acad. Sci. U.S.A. 1985; 82:879-882

Keys for Mutation Description

A.A. substitution
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted


SKUMutation DescriptionAffected Codon#Affected NT#DescriptionEffectAffected Protein Domain
RC400137 G12D12c.35G>A/CmissenseGTP binding
RC400138 G12S12c.34G>AmissenseGTP binding
RC400139 G12C12c.34G>TmissenseGTP binding
RC400140 G12V12c.35G>TmissenseGTP binding
RC400141 G12A12c.35G>CmissenseGTP binding
RC400142 Q61P61c.182A>CmissenseGTP binding
RC400143 Q61H61c.183A>TmissenseGTP binding
RC400144 Q61L61c.182A>TmissenseGTP binding
RC400145 Q61R61c.182A>GmissenseGTP binding
RC400146 Q61K61c.181C>AmissenseGTP binding
RC400147 G13C13c.37G>TmissenseGTP binding
RC400148 G13R13c.37G>CmissenseGTP binding
RC400149 A18T18c.52G>AmissenseGTP binding
RC400150 G13D13c.38G>AmissenseGTP binding
RC400151 G13V13c.38G>TmissenseGTP binding
RC400152 G13A13c.38A>CmissenseGTP binding
RC400153 G13S13c.37G>AmissenseGTP binding


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