PVRIG Human Recombinant Protein

CAT#: TP728076

Biotinylated Human PVRIG (C-Fc-Avi)

Specifications

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Thr41-Asp171
• Tag: C-Fc-Avi
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
• Note: Biotinylated Recombinant Human Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Thr41-Asp171 is expressed with a Fc, Avi tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 79037
• UniProt ID: Q6DKI7
• Summary: Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.