Interleukin-1 beta / IL-1B Chicken Protein
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Other products for "IL1B"
Specifications
Product Data | |
Species | Chicken |
Concentration | lot specific |
Purity | >85% by Ni chelate Chromatography |
Buffer | State: Liquid purified protein Buffer System: Phosphate buffered saline |
Preparation | Liquid purified protein |
Applications | In vitro Assay. Functional Assays. |
Protein Description | His-tagged recombinant chicken interleukin-1 beta expressed in E.coli. This antigen induces corticosterone secretion in vivo(1) and is the immunogen used to produce chicken IL-1beta antibody product code SP2127A. |
Storage | Store the protein at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: 3 month from despatch. |
Reference Data | |
RefSeq | NP_000567 |
Locus ID | 3553 |
UniProt ID | P01584 |
Cytogenetics | 2q14.1 |
Synonyms | IL-1; IL1-BETA; IL1beta; IL1F2 |
Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus |
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