Mtap Mouse Gene Knockout Kit (CRISPR)

CAT#: KN310456LP

Mtap - mouse gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: Mtap
• Locus ID: 66902
• Components:

  KN310456G1, Mtap gRNA vector 1 in pCas-Guide CRISPR vector

  KN310456G2, Mtap gRNA vector 2 in pCas-Guide CRISPR vector

  KN310456LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_024433
• UniProt ID: Q9CQ65
• Synonyms: 1300019I21Rik; MSAP
• Summary: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.[UniProtKB/Swiss-Prot Function]