Atp6ap2 Mouse Gene Knockout Kit (CRISPR)

CAT#: KN301806RB

Atp6ap2 - mouse gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: Atp6ap2
• Locus ID: 70495
• Components:

  KN301806G1, Atp6ap2 gRNA vector 1 in pCas-Guide CRISPR vector

  KN301806G2, Atp6ap2 gRNA vector 2 in pCas-Guide CRISPR vector

  KN301806RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_027439
• UniProt ID: Q9CYN9
• Synonyms: (P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2; ATP6M8-9; M8-9; PRR
• Summary: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity).[UniProtKB/Swiss-Prot Function]