Calcium independent Phospholipase A2 (PLA2G6) Human Gene Knockout Kit (CRISPR)

CAT#: KN207546BN

PLA2G6 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: Calcium independent Phospholipase A2
• Locus ID: 8398
• Components:

  KN207546G1, Calcium independent Phospholipase A2 gRNA vector 1 in pCas-Guide CRISPR vector

  KN207546G2, Calcium independent Phospholipase A2 gRNA vector 2 in pCas-Guide CRISPR vector

  KN207546BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001004426, NM_001199562, NM_003560, NM_001349864, NM_001349865, NM_001349866, NM_001349867, NM_001349868, NM_001349869
• UniProt ID: O60733
• Synonyms: CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9
• Summary: The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]