Plzf (ZBTB16) Human Gene Knockout Kit (CRISPR)

CAT#: KN206745RB

ZBTB16 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: Plzf
• Locus ID: 7704
• Components:

  KN206745G1, Plzf gRNA vector 1 in pCas-Guide CRISPR vector

  KN206745G2, Plzf gRNA vector 2 in pCas-Guide CRISPR vector

  KN206745RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001018011, NM_006006, NM_001354750, NM_001354751, NM_001354752
• UniProt ID: Q05516
• Synonyms: PLZF; ZNF145
• Summary: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]