Mouse Acvr1c activation kit by CRISPRa

CAT#: GA215997

Acvr1c CRISPRa kit - CRISPR gene activation of mouse activin A receptor, type IC

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Acvr1c
• Locus ID: 269275
• Kit Components:

  GA215997G1, Acvr1c gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA215997G2, Acvr1c gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA215997G3, Acvr1c gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033369, NM_001111030
• UniProt ID: Q8K348
• Synonyms: ACTR-IC; ACVRLK7; Alk-7; ALK7; C230097P10
• Summary: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.[UniProtKB/Swiss-Prot Function]