Mouse Tap2 activation kit by CRISPRa

CAT#: GA204209

Tap2 CRISPRa kit - CRISPR gene activation of mouse transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Tap2
• Locus ID: 21355
• Kit Components:

  GA204209G1, Tap2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204209G2, Tap2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204209G3, Tap2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_011530
• UniProt ID: P36371
• Synonyms: ABC18; Abcb3; AI462429; APT2; Ham-2; Ham2; jas; MTP2; PSF2; RING11; Tap-2; Y1
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]