Mouse Bad activation kit by CRISPRa

CAT#: GA200364

Bad CRISPRa kit - CRISPR gene activation of mouse BCL2-associated agonist of cell death

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Bad
• Locus ID: 12015
• Kit Components:

  GA200364G1, Bad gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200364G2, Bad gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200364G3, Bad gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001285453, NM_007522
• UniProt ID: Q61337
• Synonyms: AI325008; Bbc2
• Summary: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.[UniProtKB/Swiss-Prot Function]