Human Suppressor of Fused (SUFU) activation kit by CRISPRa

CAT#: GA109940

SUFU CRISPRa kit - CRISPR gene activation of human SUFU negative regulator of hedgehog signaling

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: SUFU
• Locus ID: 51684
• Kit Components:

  GA109940G1, Suppressor of Fused gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109940G2, Suppressor of Fused gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109940G3, Suppressor of Fused gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001178133, NM_016169
• UniProt ID: Q9UMX1
• Synonyms: PRO1280; SUFUH; SUFUXL
• Summary: The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]