Human PLA2G3 activation kit by CRISPRa

CAT#: GA109416

PLA2G3 CRISPRa kit - CRISPR gene activation of human phospholipase A2 group III

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PLA2G3
• Locus ID: 50487
• Kit Components:

  GA109416G1, PLA2G3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109416G2, PLA2G3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109416G3, PLA2G3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015715
• UniProt ID: Q9NZ20
• Synonyms: GIII-SPLA2; sPLA2-III; SPLA2III
• Summary: This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]