Human POLD3 activation kit by CRISPRa

CAT#: GA107339

POLD3 CRISPRa kit - CRISPR gene activation of human DNA polymerase delta 3, accessory subunit

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: POLD3
• Locus ID: 10714
• Kit Components:

  GA107339G1, POLD3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107339G2, POLD3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107339G3, POLD3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006591, NR_046409, NR_046410, NM_001363597
• UniProt ID: Q15054
• Synonyms: P66; P68; PPP1R128
• Summary: This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]