Human TMEM147 activation kit by CRISPRa

CAT#: GA107112

TMEM147 CRISPRa kit - CRISPR gene activation of human transmembrane protein 147

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TMEM147
• Locus ID: 10430
• Kit Components:

  GA107112G1, TMEM147 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107112G2, TMEM147 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107112G3, TMEM147 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001242597, NM_001242598, NM_006326, NM_032635
• UniProt ID: Q9BVK8
• Synonyms: NIFIE14
• Summary: Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (PubMed:21056967). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (PubMed:21056967).[UniProtKB/Swiss-Prot Function]