Human RASGRP2 activation kit by CRISPRa

CAT#: GA106963

RASGRP2 CRISPRa kit - CRISPR gene activation of human RAS guanyl releasing protein 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: RASGRP2
• Locus ID: 10235
• Kit Components:

  GA106963G1, RASGRP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106963G2, RASGRP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106963G3, RASGRP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001098670, NM_001098671, NM_001318398, NM_005825, NM_153819
• UniProt ID: Q7LDG7
• Synonyms: CALDAG-GEFI; CDC25L
• Summary: The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]