Human MPZL (MPZL1) activation kit by CRISPRa

CAT#: GA105992

MPZL1 CRISPRa kit - CRISPR gene activation of human myelin protein zero like 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MPZL1
• Locus ID: 9019
• Kit Components:

  GA105992G1, MPZL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105992G2, MPZL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105992G3, MPZL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146191, NM_003953, NM_024569
• UniProt ID: O95297
• Synonyms: MPZL1b; PZR; PZR1b; PZRa; PZRb
• Summary: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.[UniProtKB/Swiss-Prot Function]