Human Thyroid Hormone Receptor beta (THRB) activation kit by CRISPRa

CAT#: GA104871

THRB CRISPRa kit - CRISPR gene activation of human thyroid hormone receptor beta

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: THRB
• Locus ID: 7068
• Kit Components:

  GA104871G1, Thyroid Hormone Receptor beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104871G2, Thyroid Hormone Receptor beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104871G3, Thyroid Hormone Receptor beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000461, NM_001128176, NM_001128177, NM_001252634, NM_001354708, NM_001354709, NM_001354710, NM_001354711, NM_001354712, NM_001354713, NM_001354714, NM_001354715
• UniProt ID: P10828
• Synonyms: C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2
• Summary: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]