Human Tapasin (TAPBP) activation kit by CRISPRa

CAT#: GA104750

TAPBP CRISPRa kit - CRISPR gene activation of human TAP binding protein

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TAPBP
• Locus ID: 6892
• Kit Components:

  GA104750G1, Tapasin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104750G2, Tapasin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104750G3, Tapasin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003190, NM_172208, NM_172209
• UniProt ID: O15533
• Synonyms: NGS17; TAPA; TPN; TPSN
• Summary: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]