Human alpha Synuclein (SNCA) activation kit by CRISPRa

CAT#: GA104535

SNCA CRISPRa kit - CRISPR gene activation of human synuclein alpha

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: SNCA
• Locus ID: 6622
• Kit Components:

  GA104535G1, alpha Synuclein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104535G2, alpha Synuclein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104535G3, alpha Synuclein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000345, NM_001146054, NM_001146055, NM_007308
• UniProt ID: P37840
• Synonyms: NACP; PARK1; PARK4; PD1
• Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]