Human Retinoic Acid Receptor alpha (RARA) activation kit by CRISPRa

CAT#: GA104024

RARA CRISPRa kit - CRISPR gene activation of human retinoic acid receptor alpha

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: RARA
• Locus ID: 5914
• Kit Components:

  GA104024G1, Retinoic Acid Receptor alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104024G2, Retinoic Acid Receptor alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104024G3, Retinoic Acid Receptor alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000964, NM_001024809, NM_001033603, NM_001145301, NM_001145302
• UniProt ID: P10276
• Synonyms: NR1B1; RAR
• Summary: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]