Human Prolactin Receptor (PRLR) activation kit by CRISPRa

CAT#: GA103805

PRLR CRISPRa kit - CRISPR gene activation of human prolactin receptor

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PRLR
• Locus ID: 5618
• Kit Components:

  GA103805G1, Prolactin Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103805G2, Prolactin Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103805G3, Prolactin Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000949, NM_001204314, NM_001204315, NM_001204316, NM_001204317, NM_001204318, NR_037910
• UniProt ID: P16471
• Synonyms: HPRL; hPRLrI; MFAB
• Summary: This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]