Human MSH2 activation kit by CRISPRa

CAT#: GA102977

MSH2 CRISPRa kit - CRISPR gene activation of human mutS homolog 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MSH2
• Locus ID: 4436
• Kit Components:

  GA102977G1, MSH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102977G2, MSH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102977G3, MSH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000251, NM_001258281
• UniProt ID: P43246
• Synonyms: COCA1; FCC1; HNPCC; HNPCC1; LCFS2
• Summary: This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]