Human MPST activation kit by CRISPRa

CAT#: GA102967

MPST CRISPRa kit - CRISPR gene activation of human mercaptopyruvate sulfurtransferase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MPST
• Locus ID: 4357
• Kit Components:

  GA102967G1, MPST gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102967G2, MPST gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102967G3, MPST gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001013436, NM_001013440, NM_001130517, NM_021126, NR_024038, NM_001369905, NM_001369904
• UniProt ID: P25325
• Synonyms: MST; TST2; TUM1
• Summary: This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]