Human HSD3B2 activation kit by CRISPRa

CAT#: GA102244

HSD3B2 CRISPRa kit - CRISPR gene activation of human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: HSD3B2
• Locus ID: 3284
• Kit Components:

  GA102244G1, HSD3B2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102244G2, HSD3B2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102244G3, HSD3B2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000198, NM_001166120
• UniProt ID: P26439
• Synonyms: HSD3B; HSDB; SDR11E2
• Summary: The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]