Human HLCS activation kit by CRISPRa

CAT#: GA102142

HLCS CRISPRa kit - CRISPR gene activation of human holocarboxylase synthetase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: HLCS
• Locus ID: 3141
• Kit Components:

  GA102142G1, HLCS gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102142G2, HLCS gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102142G3, HLCS gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000411, NM_001242784, NM_001242785, NM_001352514, NM_001352515, NM_001352516, NM_001352517, NM_001352518, NR_148020, NR_148021
• UniProt ID: P50747
• Synonyms: HCS
• Summary: This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011]