Human GLI1 activation kit by CRISPRa

CAT#: GA101822

GLI1 CRISPRa kit - CRISPR gene activation of human GLI family zinc finger 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: GLI1
• Locus ID: 2735
• Kit Components:

  GA101822G1, GLI1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101822G2, GLI1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101822G3, GLI1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001160045, NM_001167609, NM_005269
• UniProt ID: P08151
• Synonyms: GLI
• Summary: This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]