Human DPH2 activation kit by CRISPRa

CAT#: GA101255

DPH2 CRISPRa kit - CRISPR gene activation of human diphthamide biosynthesis 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DPH2
• Locus ID: 1802
• Kit Components:

  GA101255G1, DPH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101255G2, DPH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101255G3, DPH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039589, NM_001319165, NM_001319166, NM_001319167, NM_001319168, NM_001319169, NM_001319170, NM_001319171, NM_001384, NM_201399
• UniProt ID: Q9BQC3
• Synonyms: DPH2L2
• Summary: This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]