Human Chemokine Receptor D6 (ACKR2) activation kit by CRISPRa

CAT#: GA100874

ACKR2 CRISPRa kit - CRISPR gene activation of human atypical chemokine receptor 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ACKR2
• Locus ID: 1238
• Kit Components:

  GA100874G1, Chemokine Receptor D6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100874G2, Chemokine Receptor D6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100874G3, Chemokine Receptor D6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001296
• UniProt ID: O00590
• Synonyms: CCBP2; CCR9; CCR10; CMKBR9; D6; hD6
• Summary: This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]