Dopamine D2 Receptor (DRD2) (NM_000795) Human Untagged Clone

CAT#: SC319223

DRD2 (untagged)-Human dopamine receptor D2 (DRD2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Dopamine D2 Receptor
• Synonyms: D2DR; D2R
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000795.2 GGCACGAGGGCGGGAGCTGGAAGCCTCAAGCAGCCGGCGCCGTCTCTGCCCCGGGGCGCC
  CTATGGCTTGAAGAGCCTGGCCACCCAGTGGCTCCACCGCCCTGATGGATCCACTGAATC
  TGTCCTGGTATGATGATGATCTGGAGAGGCAGAACTGGAGCCGGCCCTTCAACGGGTCAG
  ACGGGAAGGCGGACAGACCCCACTACAACTACTATGCCACACTGCTCACCCTGCTCATCG
  CTGTCATCGTCTTCGGCAACGTGCTGGTGTGCATGGCTGTGTCCCGCGAGAAGGCGCTGC
  AGACCACCACCAACTACCTGATCGTCAGCCTCGCAGTGGCCGACCTCCTCGTCGCCACAC
  TGGTCATGCCCTGGGTTGTCTACCTGGAGGTGGTAGGTGAGTGGAAATTCAGCAGGATTC
  ACTGTGACATCTTCGTCACTCTGGACGTCATGATGTGCACGGCGAGCATCCTGAACTTGT
  GTGCCATCAGCATCGACAGGTACACAGCTGTGGCCATGCCCATGCTGTACAATACGCGCT
  ACAGCTCCAAGCGCCGGGTCACCGTCATGATCTCCATCGTCTGGGTCCTGTCCTTCACCA
  TCTCCTGCCCACTCCTCTTCGGACTCAATAACGCAGACCAGAACGAGTGCATCATTGCCA
  ACCCGGCCTTCGTGGTCTACTCCTCCATCGTCTCCTTCTACGTGCCCTTCATTGTCACCC
  TGCTGGTCTACATCAAGATCTACATTGTCCTCCGCAGACGCCGCAAGCGAGTCAACACCA
  AACGCAGCAGCCGAGCTTTCAGGGCCCACCTGAGGGCTCCACTAAAGGGCAACTGTACTC
  ACCCCGAGGACATGAAACTCTGCACCGTTATCATGAAGTCTAATGGGAGTTTCCCAGTGA
  ACAGGCGGAGAGTGGAGGCTGCCCGGCGAGCCCAGGAGCTGGAGATGGAGATGCTCTCCA
  GCACCAGCCCACCCGAGAGGACCCGGTACAGCCCCATCCCACCCAGCCACCACCAGCTGA
  CTCTCCCCGACCCGTCCCACCATGGTCTCCACAGCACTCCCGACAGCCCCGCCAAACCAG
  AGAAGAATGGGCATGCCAAAGACCACCCCAAGATTGCCAAGATCTTTGAGATCCAGACCA
  TGCCCAATGGCAAAACCCGGACCTCCCTCAAGACCATGAGCCGTAGGAAGCTCTCCCAGC
  AGAAGGAGAAGAAAGCCACTCAGATGCTCGCCATTGTTCTCGGCGTGTTCATCATCTGCT
  GGCTGCCCTTCTTCATCACACACATCCTGAACATACACTGTGACTGCAACATCCCGCCTG
  TCCTGTACAGCGCCTTCACGTGGCTGGGCTATGTCAACAGCGCCGTGAACCCCATCATCT
  ACACCACCTTCAACATTGAGTTCCGCAAGGCCTTCCTGAAGATCCTCCACTGCTGACTCT
  GCTGCCTGCCCGCACAGCAGCCTGCTTCCCACCTCCCTGCCCAGGCCGGCCAGCCTCACC
  CTTGCGAACCGTGAGCAGGAAGGCCTGGGTGGATCGGCCTCCTCTTCACCCCGGCAGGCC
  CTGCAGTGTTCGCTTGGCTCCATGCTCCTCACTGCCCGCACACCCTCACTCTGCCAGGGC
  AGTGCTAGTGAGCTGGGCATGGTACCAGCCCTGGGGCTGGGCCCCCCAGCTCAGGGGCAG
  CTCATAGAGTCCCCCCTCCCACCTCCAGTCCCCCTATCCTTGGCACCAAAGATGCAGCCG
  CCTTCCTTGACCTTCCTCTGGGGCTCTAGGGTTGCTGGAGCCTGAGTCAGGGCCCAGAGG
  CTGAGTTTTCTCTTTGTGGGGCTTGGCGTGGAGCAGGCGGTGGGGAGAGATGGACAGTTC
  ACACCCTGCAAGGCCCACAGGAGGCAAGCAAGCTCTCTTGCCGAGGAGCCAGGCAACTTC
  AGTCCTGGGAGACCCATGTAAATACCAGACTGCAGGTTGGACCCCAGAGATTCCCAAGCC
  AAAAACCTTAGCTCCCTCCCGCACCCCGATGTGGACCTCTACTTTCCAGGCTAGTCCGGA
  CCCACCTCACCCCGTTACAGCTCCCCAAGTGGTTTCCACATGCTCTGAGAAGAGGAGCCC
  TCATCTTGAAGGGCCCAGGAGGGTCTATGGGGAGAGGAACTCCTTGGCCTAGCCCACCCT
  GCTGCCTTCTGACGGCCCTGCAATGTATCCCTTCTCACAGCACATGCTGGCCAGCCTGGG
  GCCTGGCAGGGAGGTCAGGCCCTGGAACTCTATCTGGGCCTGGGCTAGGGGACATCAGAG
  GTTCTTTGAGGGACTGCCTCTGCCACACTCTGACGCAAAACCACTTTCCTTTTCTATTCC
  TTCTGGCCTTTCCTCTCTCCTGTTTCCCTTCCCTTCCACTGCCTCTGCCTTAGAGGAGCC
  CACGGCTAAGAGGCTGCTGAAAACCATCTGGCCTGGCCTGGCCCTGCCCTGAGGAAGGAG
  GGGAAGCTGCAGCTTGGGAGAGCCCCTGGGGCCTAGACTCTGTAACATCACTATCCATGC
  ACCAAACTAATAAAACTTTGACGAGTCAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_000795
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000795.2, NP_000786.1
• RefSeq Size: 2643 bp
• RefSeq ORF: 1332 bp
• Locus ID: 1813
• UniProt ID: P14416
• Cytogenetics: 11q23.2
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Gap junction, Neuroactive ligand-receptor interaction
• Gene Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) encodes the longer isoform (long).