CCBL1 (KYAT1) (NM_001122672) Human Untagged Clone

CAT#: SC318844

CCBL1 (untagged)-Human cysteine conjugate-beta lyase, cytoplasmic (CCBL1), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KYAT1
• Synonyms: CCBL1; GTK; KAT1; KATI
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001122672, the custom clone sequence may differ by one or more nucleotides
  ATGGCCAAACAGCTGCAGGCCCGAAGGCTAGACGGGATCGACTACAACCCCTGGGTGGAG
  TTTGTGAAACTGGCCAGTGAGCATGACGTCGTGAACTTGGGCCAGGGCTTCCCGGATTTC
  CCACCACCAGACTTTGCCGTGGAAGCCTTTCAGCACGCTGTCAGTGGAGACTTCATGCTT
  AACCAGTACACCAAGACATTTGTCATCATCATCGAACCCTTTTTTGACTGCTACGAGCCC
  ATGACAATGATGGCAGGGGGTCGTCCTGTGTTTGTGTCCCTGAAGCCGGGTCCCATCCAG
  AATGGAGAACTGGGTTCCAGCAGCAACTGGCAGCTGGACCCCATGGAGCTGGCCGGCAAA
  TTCACATCACGCACCAAAGCCCTGGTCCTCAACACCCCCAACAACCCCCTGGGCAAGGTG
  TTCTCCAGGGAAGAGCTGGAGCTGGTGGCCAGCCTTTGCCAGCAGCATGACGTGGTGTGT
  ATCACTGATGAAGTCTACCAGTGGATGGTCTACGACGGGCACCAGCACATCAGCATTGCC
  AGCCTCCCTGGCATGTGGGAACGGACCCTGACCATCGGCAGCGCCGGCAAGACCTTCAGC
  GCCACTGGCTGGAAGGTGGGCTGGGTCCTGGGTCCAGATCACATCATGAAGCACCTGCGG
  ACCGTGCACCAGAACTCCGTCTTCCACTGCCCCACGCAGAGCCAGGCTGCAGTAGCCGAG
  AGCTTTGAACGGGAGCAGCTGCTCTTCCGCCAACCCAGCAGCTACTTTGTGCAGTTCCCG
  CAGGCCATGCAGCGCTGCCGTGACCACATGATACGTAGCCTACAGTCAGTGGGCCTGAAG
  CCCATCATCCCTCAGGGCAGCTACTTCCTCATCACAGACATCTCAGACTTCAAGAGGAAG
  ATGCCTGACTTGCCTGGAGCTGTGGATGAGCCCTATGACAGACGCTTCGTCAAGTGGATG
  ATCAAGAACAAGGGCTTGGTGGCCATCCCTGTCTCCATCTTCTATAGTGTGCCACATCAG
  AAGCACTTTGACCACTATATCCGCTTCTGTTTTGTGAAGGATGAAGCCACGCTCCAGGCC
  ATGGACGAGAAGCTGCGGAAGTGGAAGGTGGAACTC
  
• Restriction Sites: Please inquire
• ACCN: NM_001122672
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001122672.1, NP_001116144.1
• RefSeq Size: 1792 bp
• RefSeq ORF: 1119 bp
• Locus ID: 883
• UniProt ID: Q16773
• Cytogenetics: 9q34.11
• Gene Summary: This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.