Haptoglobin (HP) (BC058031) Human Untagged Clone

CAT#: SC125987

HP (untagged)-Human haptoglobin, mRNA (cDNA clone MGC:61957 IMAGE:4723094), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Haptoglobin
• Synonyms: binding peptide; BP; haptoglobin; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; HP2-ALPHA-2; HPA1S; MGC111141
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC058031 edited
  GGGGGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCT
  CCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCTAC
  CAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTGTACACCTTAAACAAT
  GGGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGT
  GGGAAGCCCAAGAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCC
  AAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCC
  ACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCA
  GAAAATGCAACAGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAG
  CTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTC
  ATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCA
  AAGGATTATGCAGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAAT
  TTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGC
  ATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGG
  GTGCAGCCCATACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGAC
  ACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGG
  TATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTAT
  GTGAAGGTGACTTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAG
  GCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAGGGCAAAGTGGACG
  GGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGC
  ATTGCTGAGTCAATCAATAAAGAGCTTTCTTTTGACACAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC058031 unedited
  CGCAGTTCAGGATTTGTAAACCACTTACTATAGGCGGCCCGAATCGCCTTACGCCGGGCT
  CTTCGAGCAANACGGGCGGAGAGGGGCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGA
  CAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCTACCAGTGTAAGAACT
  ACTACAAACTGCGCACAGAAGGAGATGGAGTGTACACCTTAAACAATGGGAAGGGGTGGA
  TAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGA
  ATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTC
  CCTGGCAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATG
  AACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAG
  CGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTG
  AGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGGTCATCAAACTCAAAC
  AGAAAGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCCTTCAAGGGTTATGCAA
  AATAAGGGCGTGTGGGTTATGGTTTCTGGCTGGGGGGCGAAATGCCAATTTTAAATTTAC
  TGACCATCTGAAGTATGTCATGCTGCCTGGGGGCGACCAAACCAATGCTAAAGGGATATG
  GAAAGGCGGCAAATCCCCCCAAAAAAGAACACCAANAGCCCTGGGGGGGGCAGCCCATAC
  TGATGGACCCCCTTCTGTGCGGGCGGTTTAAGACCAAAAAACCCCGGCTGGGGATCG
  
• Restriction Sites: Please inquire
• ACCN: BC058031
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC058031.1, AAH58031.1
• RefSeq Size: 1207 bp
• RefSeq ORF: 684 bp
• Locus ID: 3240
• Cytogenetics: 16q22.2
• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane
• Gene Summary: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]