Fibrinogen gamma chain (FGG) (NM_021870) Human Untagged Clone

CAT#: SC109240

FGG (untagged)-Human fibrinogen gamma chain (FGG), transcript variant gamma-B

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Fibrinogen gamma chain
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_021870, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAGTTGGTCCTTGCACCCCCGGAATTTAATTCTCTACTTCTATGCTCTTTTATTTCTCTCTTCAACAT
  GTGTAGCATATGTTGCTACCAGAGACAACTGCTGCATCTTAGATGAAAGATTCGGTAGTTATTGTCCAAC
  TACCTGTGGCATTGCAGATTTCCTGTCTACTTATCAAACCAAAGTAGACAAGGATCTACAGTCTTTGGAA
  GACATCTTACATCAAGTTGAAAACAAAACATCAGAAGTCAAACAGCTGATAAAAGCAATCCAACTCACTT
  ATAATCCTGATGAATCATCAAAACCAAATATGATAGACGCTGCTACTTTGAAGTCCAGGAAAATGTTAGA
  AGAAATTATGAAATATGAAGCATCGATTTTAACACATGACTCAAGTATTCGATATTTGCAGGAAATATAT
  AATTCAAATAATCAAAAGATTGTTAACCTGAAAGAGAAGGTAGCCCAGCTTGAAGCACAGTGCCAGGAAC
  CTTGCAAAGACACGGTGCAAATCCATGATATCACTGGGAAAGATTGTCAAGACATTGCCAATAAGGGAGC
  TAAACAGAGCGGGCTTTACTTTATTAAACCTCTGAAAGCTAACCAGCAATTCTTAGTCTACTGTGAAATC
  GATGGGTCTGGAAATGGATGGACTGTGTTTCAGAAGAGACTTGATGGCAGTGTAGATTTCAAGAAAAACT
  GGATTCAATATAAAGAAGGATTTGGACATCTGTCTCCTACTGGCACAACAGAATTTTGGCTGGGAAATGA
  GAAGATTCATTTGATAAGCACACAGTCTGCCATCCCATATGCATTAAGAGTGGAACTGGAAGACTGGAAT
  GGCAGAACCAGTACTGCAGACTATGCCATGTTCAAGGTGGGACCTGAAGCTGACAAGTACCGCCTAACAT
  ATGCCTACTTCGCTGGTGGGGATGCTGGAGATGCCTTTGATGGCTTTGATTTTGGCGATGATCCTAGTGA
  CAAGTTTTTCACATCCCATAATGGCATGCAGTTCAGTACCTGGGACAATGACAATGATAAGTTTGAAGGC
  AACTGTGCTGAACAGGATGGATCTGGTTGGTGGATGAACAAGTGTCACGCTGGCCATCTCAATGGAGTTT
  ATTACCAAGGTGGCACTTACTCAAAAGCATCTACTCCTAATGGTTATGATAATGGCATTATTTGGGCCAC
  TTGGAAAACCCGGTGGTATTCCATGAAGAAAACCACTATGAAGATAATCCCATTCAACAGACTCACAATT
  GGAGAAGGACAGCAACACCACCTGGGGGGAGCCAAACAGGTCAGACCAGAGCACCCTGCGGAAACAGAAT
  ATGACTCACTTTACCCTGAGGATGATTTGTAG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021870 unedited
  NGGTTTTATAAATTTGTAATACGACTCACTATAGGGCGGCCGCGAAATTCGCACCAGACA
  CTACAAGGCTCGGAGCTCCGGGCACTCAGACATCATGAGTTGGTCCTTGCACCCCCGGAA
  TTTAATTCTCTACTTCTATGCTCTTTTATTTCTCTCTTCAACATGTGTAGCATATGTTGC
  TACCAGAGACAACTGCTGCATCTTAGATGAAAGATTCGGTAGTTATTGTCCAACTACCTG
  TGGCATTGCAGATTTCCTGTCTACTTATCAAACCAAAGTAGACAAGGATCTACAGTCTTT
  GGAAGACATCTTACATCAAGTTGAAAACAAAACATCAGAAGTCAAACAGCTGATAAAAGC
  AATCCAACTCACTTATAATCCTGATGAATCATCAAAACCAAATATGATAGACGCTGCTAC
  TTTGAAGTCCAGGAAAATGTTAGAAGAAATTATGAAATATGAAGCATCGATTTTAACACA
  TGACTCAAGTATTCGATATTTGCAGGAAATATATAATTCAAATAATCAAAAGATTGTTAA
  CCTGAAAGAGAAGGTAGCCCAGCTTGAAGCACAGTGCCAGGAACCTTGCAAAGACACGGT
  GCAAATCCATGATATCACTGGGAAAGATTGTCAAGACATTGCCAATAAGGGAGCTAAACA
  GAGCGGGCTNTACTTTATTAAACCTCTGAAAGCTAACCAGCAATTCTTAGTCTACTGTGA
  AATCGATGGGTCTGGAAATGGATGGACTGTNGTTCAGAAGAGACTGATGGCAGTGTAGAT
  NTCAAGAAAACTGGATTCATATAAAGAAGATTTGNACATCTGTCTCCTACTGGCACAACA
  GAAATTTNGCTGGGAAATGAGAAGATNCATTTGATAGCACACAGTCTGCCTCCCATATGC
  ATTAAGATG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021870 unedited
  NTTTCGTTGNCCGCGGCCGCATTCNANGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTGCAAATAAAGGCAATCATTTTATTATTATATATTTAGGAACAAAGTTGAAATGTTAT
  CTCCTCAAATAAACAATTTTTAAATAACTCTGATATCAGTAATTTGGAAATACAGTCCTA
  AATGAGTTTTAATTTCCATTGAAGGCTAAATGTCCTTAATAGAAGACTTGAAATCAATAA
  ATATAGTAAGAGAAAAAAGGAAGAAACTTTCAGAGAATTTCTGAAACTTTGTGGGTCAAT
  AGAAATTAGCAGTTAATTTTCTACAAATCATCCTCAGGGTAAAGTGAGTCATATTCTGTT
  TCCGCAGGGTGCTCTGGTCTGACCTGTTTGGCTCCCCCCAGGTGGGGTTGCTGTCCTTCT
  CCAATTGTGAGTCTGTTGAATGGGATTATCTTCATAGTGGTTTTCTTCATGGAATACCAC
  CGGGTTTTCCAAGTGGCCCAAATAATGCCATTATCATAACCATTAGGAGTAGATGCTTTT
  GAGTAAGTGCCACCTTGGTAATAAACTCCATTGAGATGGCCAGCGTGACACTTGTTCATC
  CACCAACCAGATCCATCCTGTTCAGCACAGTTGCCTTCAAACTTATCATTGTCATTGTCC
  CAGGTACTGAACTGCATGCCATTATGGGATGTGAAAAACTTGTCACTAGGATCATCGCCA
  AAATCAAAGCCATCAAAGGCATCTTCAGCATCCCCACCAGCGAAGTAGGCATATGTTAAG
  CGGTACTTGTCAGCTCCAGGTCCACCTTGAACATGCCATANTCTGCAGTACTGGTTCTGC
  CATTCCAGNCTTCCAGTTCCACTCTTATGCTATGGGATGGCAGACTGTGTGCCTATCAAT
  GAATCTTTCATTTCCAGCCCAAAATCTGTTGGCACTAGAAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021870
• Insert Size: 1950 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_021870.2, NP_068656.2
• RefSeq Size: 1763 bp
• RefSeq ORF: 1362 bp
• Locus ID: 2266
• UniProt ID: P02679
• Cytogenetics: 4q32.1
• Domains: FBG
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Complement and coagulation cascades
• Gene Summary: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
  Transcript Variant: This variant (gamma-B) represents the longer transcript and encodes the longer isoform (gamma-B).