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Scn2a (NM_001099298) Mouse Tagged ORF Clone
CAT#: MG215244
- TrueORF®
Scn2a1 (tGFP-tagged) - Mouse sodium channel voltage-gated type II alpha 1 (Scn2a1), (10ug)
ORF Plasmid: DDK
"NM_001099298" in other vectors (2)
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Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | TurboGFP |
| Symbol | Scn2a |
| Synonyms | 6430408L10; A230052E19Rik; Nav; Nav1.2; Scn; Scn2a1 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MG215244 representing NM_001099298
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCACAATCAGTGCTGGTACCGCCAGGACCTGACAGCTTCCGCTTCTTTACCAGGGAATCCCTTGCTG CTATTGAACAACGCATTGCAGAAGAGAAAGCTAAGAGACCCAAACAGGAACGCAAGGACGAAGACGACGA AAATGGCCCAAAGCCAAATAGTGACTTGGAAGCAGGAAAATCCCTTCCTTTTATTTATGGAGACATTCCT CCAGAGATGGTGTCAGAGCCCCTGGAGGACCTGGACCCCTACTATATCAATAAGAAAACCTTTATAGTAT TGAATAAAGGGAAAGCAATCTCTCGGTTCAGTGCCACCTCCGCCCTGTACATTTTAACTCCCTTCAACCC CATTAGAAAATTAGCTATTAAGATTTTGGTACATTCTTTATTCAATGTGCTTATCATGTGCACAATTCTT ACCAACTGTGTATTTATGACCATGAGCAACCCTCCAGACTGGACAAAGAATGTGGAGTATACTTTTACAG GAATTTATACTTTTGAATCACTTATTAAAATACTTGCAAGGGGCTTTTGTCTAGAAGATTTCACATTTCT ACGGGATCCCTGGAACTGGCTGGATTTCACAGTCATTACCTTTGCGTATGTAACAGAATTTGTAAACCTA GGCAATGTTTCAGCTCTTCGAACTTTCAGAGTCTTGAGAGCTTTGAAAACTATTTCTGTAATTCCAGGCC TGAAGACCATCGTGGGGGCCCTGATCCAGTCGGTGAAGAAGCTGTCTGACGTCATGATACTCACTGTGTT CTGTCTGAGTGTCTTTGCTCTCATCGGGCTGCAGCTCTTCATGGGCAACCTGAGGAATAAATGCTTGCAG TGGCCCCCAGACAATTCTACCTTTGAAATAAACATCACTTCCTTCTTTAATAACTCATTGGATTGGAATG GTACTGCCTTCAATAGGACAATGAACATGTTTAACTGGGATGAATATATTGAAGATAAAAGTCACTTTTA TTTTTTGGAAGGACAAAACGATGCTCTGCTTTGTGGTAACAGCTCGGATGCTGGCCAGTGTCCGGAAGGA TACATCTGTGTGAAGGCTGGGAGAAACCCCAACTATGGCTACACGAGTTTTGACACCTTCAGCTGGGCCT TCTTGTCCTTATTTCGTCTTATGACTCAAGACTTCTGGGAAAACCTTTATCAGCTGACCTTGCGTGCTGC TGGGAAAACATATATGATATTTTTCGTGCTTGTGATTTTCTTGGGCTCATTCTACCTAATAAATTTGATC CTGGCTGTGGTGGCCATGGCCTATGAAGAACAGAACCAGGCCACGCTGGAGGAAGCTGAACAGAAGGAGG CAGAGTTTCAGCAGATGCTGGAGCAACTTAAGAAGCAGCAAGAAGAAGCTCAGGCAGCAGCTGCAGCAGC GTCTGCAGAATCCAGAGACTTCAGTGGAGCAGGTGGGATAGGTGTTTTCTCGGAGAGTTCTTCCGTAGCT TCAAAGTTAAGTTCCAAGAGTGAAAAGGAGCTGAAAAACAGAAGGAAGAAAAAGAAACAGAAAGAGCAGG CTGGAGAGGAAGAGAAGGAAGATGCTGTGCGGAAATCTGCCTCTGAAGACAGCATACGAAAGAAAGGCTT CCGGTTTTCCCTAGAAGGGAGTAGACTGACCTACGAGAAGAGGTTTTCCTCTCCACACCAGTCTCTCTTG AGCATCCGAGGCTCCCTTTTTTCTCCGAGACGCAACAGTAGAGCAAGCCTTTTCAGCTTCAAAGGTCGGG TGAAGGATATTGGTTCTGAAAATGACTTTGCGGACGATGAACACAGCACGTTTGAGGACAACGACAGCAG GAGAGACTCTCTATTTGTACCACACAGACATGGAGAAAGGCGTCCCAGCAACGTTAGCCAGGCCAGCCGT GCCTCCCGGGGGATACCCACTCTACCCATGAATGGGAAGATGCACAGTGCAGTGGACTGCAACGGTGTGG TCTCCCTAGTTGGAGGCCCTTCTGCTCTCACATCTCCTGTGGGGCAGCTACTACCAGAGGGCACAACTAC TGAAACAGAAATAAGGAAGAGGAGGTCCAGTTCTTACCATGTTTCTATGGACTTGTTGGAAGACCCTACA TCAAGGCAAAGAGCAATGAGTATGGCCAGCATTTTGACCAACACTATGGAAGAACTTGAAGAATCCAGAC AGAAATGCCCTCCATGCTGGTATAAATTTGCTAATATGTGCCTGATTTGGGACTGTTGTAAGCCATGGCT AAAGGTAAAACATGTTGTCAATCTGGTAGTGATGGATCCATTCGTTGACCTGGCCATCACCATCTGCATT GTGTTAAATACACTCTTCATGGCCATGGAGCACTACCCGATGACGGAGCAGTTCAGCAGTGTGCTGTCTG TTGGGAATTTGGTCTTCACTGGGATCTTCACCGCAGAAATGTTTCTCAAGATAATAGCCATGGATCCATA TTATTACTTTCAAGAAGGCTGGAATATCTTTGATGGCTTTATAGTGAGCCTTAGTTTAATGGAACTCGGC TTGGCGAATGTGGAAGGACTGTCAGTTCTCCGATCTTTCCGACTGCTTAGAGTCTTCAAGTTGGCAAAAT CCTGGCCCACACTGAATATGCTCATTAAGATCATCGGCAACTCGGTGGGCGCGCTGGGCAACCTGACCCT GGTGCTGGCCATCATCGTCTTCATTTTTGCCGTGGTCGGCATGCAGCTGTTTGGAAAGAGCTACAAGGAG TGTGTTTGCAAGATTTCCAATGATTGTGAGCTGCCGCGCTGGCACATGCATGACTTCTTCCACTCGTTCC TGATCGTGTTCCGCGTGCTGTGTGGGGAGTGGATAGAGACCATGTGGGACTGCATGGAGGTCGCAGGCCA GACCATGTGTCTTACTGTCTTCATGATGGTCATGGTGATTGGGAACCTTGTCGTTCTGAACCTCTTCTTG GCCTTGCTCCTCAGTTCTTTCAGCTCGGACAACCTGGCTGCCACAGATGACGATAACGAAATGAACAACC TCCAGATAGCCGTGGGAAGGATGCAGAAGGGGATTGATTTTGTTAAAAGGAAGATACGTGAATTCATTCA GAAAGCCTTTGTCAGAAAGCAGAAAGCTCTAGATGAAATCAAACCCCTTGAAGATCTGAATAACAAGAAA GACAGTTGTATCTCCAACCACACAACCATAGAAATAGGCAAGGACCTGAATTACCTCAAAGATGGAAACG GGACGACCAGTGGCATAGGCAGCAGTGTGGAGAAGTACGTGGTAGATGAGAGTGATTACATGTCATTCAT CAACAACCCCAGCCTCACCGTGACTGTGCCCATTGCTGTGGGAGAGTCTGACTTTGAAAACTTAAATACA GAAGAATTCAGCAGTGAATCAGATATGGAAGAAAGCAAGGAGAAATTGAATGCAACTAGTTCATCTGAAG GCAGTACAGTTGATATAGGTGCTCCTGCAGAGGGAGAGCAACCAGAGGCCGAACCAGAAGAGTCCCTTGA GCCAGAAGCCTGTTTCACAGAAGACTGTGTAAGAAAGTTCAAGTGTTGTCAGATAAGCATAGAAGAAGGC AAAGGCAAACTCTGGTGGAACTTGAGGAAAACCTGCTACAAGATAGTAGAGCACAACTGGTTTGAAACCT TCATCGTCTTCATGATTCTGCTCAGCAGCGGTGCTCTGGCCTTTGAAGACATTTACATCGAGCAGCGAAA AACCATCAAGACCATGCTGGAGTATGCTGACAAGGTCTTCACTTACATCTTCATCCTGGAGATGTTGCTA AAGTGGGTTGCATATGGTTTCCAAATGTACTTCACCAATGCCTGGTGCTGGCTGGACTTCCTGATCGTTG ATGTCTCACTGGTTAGCTTAACTGCAAATGCCTTGGGCTATTCAGAACTTGGTGCCATCAAATCCCTCCG AACATTAAGAGCACTGAGGCCTCTACGAGCCTTATCCCGATTTGAAGGAATGAGGGTTGTTGTAAACGCT CTCCTAGGTGCAATCCCATCCATAATGAACGTACTTCTGGTCTGCCTGATCTTTTGGCTAATATTCAGTA TCATGGGGGTGAATCTCTTTGCCGGCAAGTTCTATCATTGCATCAACTACACCACCGGGGAAATGTTTGA TGTGAGCGTGGTCAACAACTACAGTGAGTGCCAGGCTCTCATAGAGAGCAATCAGACAGCCAGGTGGAAG AATGTGAAAGTCAACTTTGACAACGTGGGACTTGGATATCTTTCTCTGCTTCAAGTAGCCACATTTAAAG GATGGATGGATATCATGTATGCAGCTGTTGACTCAAGAAATGTAGAACTGCAACCCAAATATGAAGACAA TCTATACATGTACCTTTACTTTGTCATCTTTATTATTTTCGGCTCATTCTTCACACTGAACCTGTTCATC GGCGTCATCATAGATAACTTCAACCAACAGAAGAAGAAGTTTGGAGGTCAAGACATTTTTATGACAGAAG AACAGAAGAAATACTACAATGCAATGAAGAAGCTAGGCTCAAAGAAACCACAAAAACCGATACCTCGCCC TGCTAACAAGTTTCAAGGGATGGTCTTTGATTTTGTAACCAAACAAGTGTTTGACATCAGCATCATGATC CTCATCTGCCTCAACATGGTGACCATGATGGTGGAAACGGACGACCAGAGCCAAGAGATGACCAACATCC TGTATTGGATCAACCTGGTGTTCATCGTCCTGTTCACCGGCGAGTGTGTGCTCAAGCTTATCTCACTCCG TCATTATTATTTCACCATTGGATGGAACATTTTTGATTTTGTGGTGGTCATCCTCTCCATTGTAGGGATG TTTCTCGCGGAGCTGATAGAGAAGTATTTCGTGTCCCCTACCCTGTTCCGAGTCATCCGCCTGGCCAGGA TTGGACGAATCCTACGCCTGATCAAAGGCGCCAAGGGGATCCGCACGCTGCTCTTTGCTCTGATGATGTC CCTTCCTGCGCTGTTTAACATCGGCCTCCTGCTTTTCCTGGTCATGTTCATCTACGCCATCTTTGGGATG TCCAACTTTGCCTACGTTAAGAGGGAAGTTGGGATTGATGACATGTTCAACTTTGAGACCTTTGGCAACA GCATGATCTGCCTGTTCCAAATCACCACTTCTGCGGGCTGGGATGGACTGCTGGCCCCTATACTAAATAG TGGACCTCCCGATTGTGACCCTGAAAAAGATCATCCTGGAAGCTCGGTGAAGGGAGACTGTGGGAACCCA TCTGTGGGGATTTTCTTTTTTGTCAGCTACATCATCATATCCTTCCTGGTTGTGGTGAACATGTACATTG CTGTCATCCTGGAGAACTTCAGCGTTGCCACAGAAGAAAGTGCAGAGCCTCTGAGTGAGGACGACTTTGA GATGTTCTACGAAGTCTGGGAGAAGTTCGACCCTGACGCCACCCAGTTCATAGAGTTCTGCAAGCTCTCT GACTTTGCAGCTGCCCTGGATCCTCCCCTCCTCATCGCAAAGCCAAACAAAGTGCAGCTCATTGCCATGG ACCTGCCCATGGTGAGTGGAGACCGCATCCACTGCCTGGACATCTTATTTGCTTTTACAAAGCGGGTCCT GGGTGAGAGTGGAGAGATGGATGCTCTTCGAATCCAGATGGAAGAGCGGTTCATGGCTTCCAATCCCTCC AAGGTCTCTTATGAGCCCATTACCACCACTCTGAAGCGCAAACAAGAGGAGGTGTCTGCTATTGTCATCC AGCGAGCTTACAGACGCTATCTTCTGAAACAGAAAGTTAAGAAGGTTTCGTCTATATATAAAAAAGACAA GGGTAAAGAAGATGAGGGAACGCCCATCAAAGAAGACATCATCACGGATAAACTGAATGAGAATTCAACT CCAGAGAAGACTGACGTGACACCCTCCACCACTTCGCCACCTTCCTACGATAGCGTGACCAAACCGGAGA AGGAAAAATTTGAAAAGGACAAATCAGAAAAAGAGGACAAGGGGAAAGATATCAGGGAAAGTAAAAAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG215244 representing NM_001099298
Red=Cloning site Green=Tags(s) MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIP PEMVSEPLEDLDPYYINKKTFIVLNKGKAISRFSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTIL TNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNL GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQ WPPDNSTFEINITSFFNNSLDWNGTAFNRTMNMFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEG YICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVA SKLSSKSEKELKNRRKKKKQKEQAGEEEKEDAVRKSASEDSIRKKGFRFSLEGSRLTYEKRFSSPHQSLL SIRGSLFSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRPSNVSQASR ASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPT SRQRAMSMASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHVVNLVVMDPFVDLAITICI VLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG LANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE CVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL ALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKK DSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEPEESLEPEACFTEDCVRKFKCCQISIEEG KGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLL KWVAYGFQMYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWK NVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFI GVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMI LICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGM FLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNP SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLS DFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPS KVSYEPITTTLKRKQEEVSAIVIQRAYRRYLLKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENST PEKTDVTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001099298 |
| ORF Size | 6018 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001099298.3 |
| RefSeq Size | 8690 bp |
| RefSeq ORF | 6021 bp |
| Locus ID | 110876 |
| UniProt ID | B1AWN6 |
| Cytogenetics | 2 38.61 cM |
| Gene Summary | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
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