RUNX1T1 Rabbit Polyclonal Antibody

CAT#: TA590310

Rabbit Polyclonal RUNX1T1/ETO Antibody

Product Images

ELISA: RUNX1T1 / ETO Antibody

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: WB: 1:5000-1:20000; ELISA: 1:100-1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 0.99708 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: RUNX1 partner transcriptional co-repressor 1
• Database Link:
  NP_783553
  Entrez Gene 862 Human
  UniProt ID Q06455
• Background: The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
• Synonyms: AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer